The Modified Glassy Carbon Electrode by MWCNTs-PLL to Detect Both Paracetamol and Ibuprofen in Human Biological Fluid

Abstract

The MWCNTs-PLL material was effectively synthesized in this study. The UV–vis spectrum and FT-IR spectroscopy are used to determine the structure of nanoparticles. The electrochemical characteristics of glassy carbon electrodes (GCE) were examined after the MWCNTs-PLL material with nanosized particles was dropped onto its surface to create MWCNTs-PLL/GCE. Furthermore, employing electrodes, PAR and IBU were examined via applying CV and DP-ASV techniques. In comparison to employing the bare GCE, the modified MWCNTs-PLL/GCE electrode showed good responsiveness toward PAR and IBU applying the DP-ASV technique, with LODs were 0.40 for PAR, 0.34 μM for IBU. The linear concentrations ranged from 1.0 to 210 μM. These factors like Na+, SO4 2−, CO3 2−, K+, Ca2+, Cl−, Mg2+, NH4 +, NO3 − ions, uric acid, oxalate and AA, did not interfere during the modified electrode’s operation. Within this paper, it is worth emphasizing that these analytical processes for the PAR and IBU in practical sample solutions are more dependable than the HPLC tool. Additionally, this work would be considered the state-of-the-art study for both using MWCNTs-PLL to simultaneously determine PAR and IBU, and employing successfully the cheap, fast, reliable method.