Targeting thrombomodulin to circulating red blood cells augments its protective effects in models of endotoxemia and ischemia‐reperfusion injury

Author:

Carnemolla Ronald12,Villa Carlos H.123,Greineder Colin F.12,Zaitsev Sergei123,Patel Kruti R.4,Kowalska M. Anna56,Atochin Dmitriy N.7,Cines Douglas B.3,Siegel Don L.3,Esmon Charles T.89,Muzykantov Vladimir R.12

Affiliation:

1. Department of PharmacologyUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

2. Center for Targeted Therapeutics and Translational NanomedicineInstitute for Translational Medicine and TherapeuticsUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

3. Department of Pathology and Laboratory MedicineThe Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

4. Department of MedicineBrigham and Women's HospitalBostonMassachusettsUSA

5. Division of Hematology, Department of PediatricsThe Children's Hospital of PhiladelphiaPhiladelphiaPennsylvaniaUSA

6. Institute of Medical BiologyPolish Academy of SciencesLodzPoland

7. Division of Cardiology, Cardiovascular Research CenterMassachusetts General HospitalCharlestownMassachusettsUSA

8. Department of PathologyOklahoma Medical Research FoundationOklahoma CityOklahomaUSA

9. Department of Biochemistry and Molecular Biology, Coagulation Biology LaboratoryOklahoma Medical Research FoundationOklahoma CityOklahomaUSA

Funder

National Institutes of Health

National Heart, Lung, and Blood Institute

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

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