Mathematical study of nanoparticle loaded in red blood cells for drug delivery in an artery with stenosis

Abstract

Nanoparticles (NPs) offer a revolutionary platform in order to achieve targeted delivery for the treatment of cardiovascular diseases. Encapsulation of NPs or nanodrugs by the process of osmosis, inside red blood cells (RBCs), is a new technique in this regard. RBCs loaded with nanodrugs enhance the bio-availability and bio-compatibility. Mathematical model for the analysis of this RBCs loaded with NPs in blood has been developed for a catheterized artery with stenosis. The RBCs loaded with NPs in blood is described as nanofluid. The temperature and velocity of resultant nanofluid have been analyzed. Graphs have been plotted using MATLAB bvp4c for various values of particle radius and membrane thickness. It has been observed that RBCs loaded with NPs concentrate highly at the stenosis thus aid in dissolving it. Also, it has been examined that an optimum NP with a radius of 100 nm is suitable for the purpose. The outcomes shall be useful for the improvement of pharmacokinetics of nanodrugs.