1. Third Department of MedicineShiga University of Medical ScienceSeta, OtsuShiga 520‐2192Japan
2. Department of PathologyOtowa HospitalYamashinaKyoto607–8062Japan
3. Lilly Research LaboratoriesIndianapolisIndianapolis46285USA
4. Research DivisionJoslin Diabetes Center and Department of MedicineBrigham and Women's Hospital and Harvard Medical SchoolBostonMassachusetts02215USA