Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin‐deficient mdx mice: proof‐of‐concept study and independent validation of efficacy
Author:
Affiliation:
1. Pharmacology UnitDepartment of Pharmacy–Drug SciencesUniversity of BariBariItaly
2. Agada Biosciences, IncorporatedHalifaxNova ScotiaCanada
3. Binghamton UniversitySchool of Pharmacy and Pharmaceutical SciencesBinghamtonNew YorkUSA
Funder
Muscular Dystrophy Association
National Institutes of Health
Publisher
Wiley
Subject
Genetics,Molecular Biology,Biochemistry,Biotechnology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1096/fj.201700182RRR
Reference63 articles.
1. Membrane protein kinase alteration in Duchenne muscular dystrophy
2. Dystrophin and disease
3. Dystrophin: The protein product of the duchenne muscular dystrophy locus
4. Deficiency of a glycoprotein component of the dystrophin complex in dystrophic muscle
5. Dystrophin-associated proteins are greatly reduced in skeletal muscle from mdx mice.
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