The <scp>SLC26A9</scp> inhibitor <scp>S9‐A13</scp> provides no evidence for a role of <scp>SLC26A9</scp> in airway chloride secretion but suggests a contribution to regulation of <scp>ASL pH</scp> and gastric proton secretion-Reference-Cited by-同舟云学术

The SLC26A9 inhibitor S9‐A13 provides no evidence for a role of SLC26A9 in airway chloride secretion but suggests a contribution to regulation of ASL pH and gastric proton secretion

Published:2022-10-02 Issue:11 Volume:36 Page:
ISSN:0892-6638
Container-title:The FASEB Journal
language:en
Short-container-title:The FASEB Journal

Author:

Jo Sungwoo¹,Centeio Raquel²,Park Jinhong¹,Ousingsawat Jiraporn²,Jeon Dong‐kyu¹,Talbi Khaoula³,Schreiber Rainer²,Ryu Kunhi¹,Kahlenberg Kristin³,Somoza Veronika³,Delpiano Livia⁴,Gray Michael A.⁴,Amaral Margarida D.⁵,Railean Violeta⁵,Beekman Jeffrey M.⁶,Rodenburg Lisa W.⁶,Namkung Wan¹,Kunzelmann Karl²^ORCID

Affiliation:

1. College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences Yonsei University Incheon South Korea

2. Physiological Institute, University of Regensburg Regensburg Germany

3. Leibniz Institute for Food Systems Biology at the Technical University of Munich Freising Germany

4. Biosciences Institute, Faculty of Medical Sciences Newcastle University Newcastle upon Tyne UK

5. BioISI—Biosystems & Integrative Sciences Institute, Faculty of Sciences University of Lisboa Lisbon Portugal

6. Regenerative Medicine Utrecht University Medical Center, Utrecht University Utrecht Netherlands

Funder

Gilead Sciences

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1096/fj.202200313RR

Reference47 articles.

1. SLC26A9 is a Cl−channel regulated by the WNK kinases

2. Characterization of SLC26A9, Facilitation of Cl^- Transport by Bicarbonate

3. Slc26a9—Anion Exchanger, Channel and Na+ Transporter

4. SLC26A9 is a constitutively active, CFTR-regulated anion conductance in human bronchial epithelia

5. Loss of Slc26a9 anion transporter alters intestinal electrolyte and HCO3 - transport and reduces survival in CFTR-deficient mice

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