Mcm2 hypomorph leads to acute leukemia or hematopoietic stem cell failure, dependent on genetic context-Reference-Cited by-同舟云学术

Mcm2 hypomorph leads to acute leukemia or hematopoietic stem cell failure, dependent on genetic context

Published:2022-08-03 Issue:9 Volume:36 Page:
ISSN:0892-6638
Container-title:The FASEB Journal
language:en
Short-container-title:The FASEB Journal

Author:

Matsukawa Toshihiro¹^ORCID,Yin Mianmian¹,Baslan Timour²,Chung Yang Jo¹,Cao Dengchao¹,Bertoli Ryan¹,Zhu Yuelin J.¹,Walker Robert L.¹,Freeland Amy³,Knudsen Erik³,Lowe Scott W.²⁴,Meltzer Paul S.¹,Aplan Peter D.¹^ORCID

Affiliation:

1. Genetics Branch, Center for Cancer Research National Cancer Institute, National Institutes of Health Bethesda Maryland USA

2. Cancer Biology and Genetics Program Sloan‐Kettering Institute New York New York USA

3. Department of Molecular and Cellular Biology Roswell Park Cancer Institute Buffalo New York USA

4. Howard Hughes Medical Institute Chevy Chase Maryland USA

Funder

National Cancer Institute

Memorial Sloan-Kettering Cancer Center

Naito Foundation

Uehara Memorial Foundation

Publisher

Wiley

Subject

Genetics,Molecular Biology,Biochemistry,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1096/fj.202200061RR

Reference51 articles.

1. DNA Replication Stress as a Hallmark of Cancer

2. Mechanisms for initiating cellular DNA replication

3. Uninterrupted MCM2-7 Function Required for DNA Replication Fork Progression

4. Sequential ATP Hydrolysis by Cdc6 and ORC Directs Loading of the Mcm2-7 Helicase

5. Reduced Mcm2 Expression Results in Severe Stem/Progenitor Cell Deficiency and Cancer

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