Inhibition of endothelial cell proliferation and angiogenesis by orlistat, a fatty acid synthase inhibitor
Author:
Affiliation:
1. Cancer Research CenterBurnham Institute for Medical ResearchLa JollaCaliforniaUSA
2. Immunology and Genetics DivisionJohn Curtin School of Medical ResearchThe Australian National UniversityCanberraACT0200Australia
Funder
National Institutes of Health
California Breast Cancer Research Program
Publisher
Wiley
Subject
Genetics,Molecular Biology,Biochemistry,Biotechnology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1096/fj.05-5404com
Reference36 articles.
1. Orlistat Is a Novel Inhibitor of Fatty Acid Synthase with Antitumor Activity
2. Activation of mitogen-activated protein kinases by vascular endothelial growth factor and basic fibroblast growth factor in capillary endothelial cells is inhibited by the antiangiogenic factor 16-kDa N-terminal fragment of prolactin.
3. The Vascular Endothelial Growth Factor Proteins: Identification of Biologically Relevant Regions by Neutralizing Monoclonal Antibodies
4. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
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