Method for determining the biological age of arteries

Abstract

Abstract. Determining the biological age of the human arteries is relevant for timely stratification of the risk of developing diseases, prevention, control of individual ageing rate, and geroprotective therapy. To study age-related changes in the echocardiographic examination of the arteries and to develop a formula for estimating the biological age of the human arteries. Echocardiographic examinations of the heart were performed on 188 practically healthy people aged 30 to 79 years (73 men and 115 women), who signed informed consent and had no clinically significant diseases in the anamnesis or at the moment. The study of the carotid and vertebral arteries of the neck was performed on the Xario SSA-660A device from Toshiba (Japan) according to the standard method using a PLT-704SBT 7.5 MHz probe. Based on the data of the study by the method of step-by-step multiple linear regressions, a formula for estimating the biological age of the human arteries was obtained. The multiple correlation coefficient after error correction was a fairly high value of R=0.894 (p˂0.00001). The mean absolute error of age calculation (M±Ϭ) is 5.11±3.51 years. The proposed formula for determining the biological age of the arteries can be used for the early diagnosis of accelerated ageing. Keywords: biological age; ultrasound examination of the main vessels of the neck