BIOLOGICAL AGE OF PHYSIOLOGICAL SYSTEMS OF THE ORGANISM AND PROFILE OF HUMAN AGING

Abstract

Aim of the study: comprehensive assessment of the rate of aging of the main physiological systems of the body and analysis of the relationships between them. Materials and methods. 188 practically healthy people of various ages (73 men and 115 women) were examined. Methods: anthropometry, echocardiography with Doppler, spirography, ECG with heart rhythm variability analysis, dual X-ray absorptiometry, clinical laboratory biochemical tests. Results. The method of stepwise multiple regression with systematic error correction was used to calculate the formulas of biological age (BA) of the cardiovascular, respiratory, musculoskeletal systems, autonomic regulation, and metabolic age. The obtained formulas make it possible to estimate the rate of aging of the body’s physiological systems with high accuracy (error of 4–5 years). An original method of calculating the integral BA based on the BA of separate body systems is proposed. Conclusion. By calculating the BA of many body systems, it is possible to estimate the rate of aging of these systems and build a human aging profile. This makes it possible to predict the risk of developing one or another age-related pathology and purposefully apply the necessary treatment and preventive measures. A comprehensive assessment of the rate of aging of the body’s physiological systems made it possible to study the heterochrony of aging, the main trajectories of the body’s aging. The connections between the aging of different body systems revealed in our research are important for the development of a strategy for antiaging effects and prevention of age-related pathology. Keywords: biological age, physiological systems, aging profile