Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor-Reference-Cited by-同舟云学术

Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor

Published:2015-08-10 Issue:5 Volume:23 Page:358-374
ISSN:1523-0864
Container-title:Antioxidants & Redox Signaling
language:en
Short-container-title:Antioxidants & Redox Signaling

Author:

Hirano Kazufumi¹,Chen Woei Shin¹,Chueng Adeline L.W.¹,Dunne Angela A.¹,Seredenina Tamara²,Filippova Aleksandra²,Ramachandran Sumitra¹,Bridges Angela³,Chaudry Laiq³,Pettman Gary³,Allan Craig³,Duncan Sarah¹,Lee Kiew Ching¹,Lim Jean¹,Ma May Thu¹,Ong Agnes B.¹,Ye Nicole Y.¹,Nasir Shabina¹,Mulyanidewi Sri¹,Aw Chiu Cheong¹,Oon Pamela P.¹,Liao Shihua⁴,Li Dizheng⁴,Johns Douglas G.⁵,Miller Neil D.¹,Davies Ceri H.¹,Browne Edward R.¹,Matsuoka Yasuji¹,Chen Deborah W.¹,Jaquet Vincent²,Rutter A. Richard¹

Affiliation:

1. Neural Pathways Discovery Performance Unit, Neurosciences Therapeutic Area, GlaxoSmithKline, Biopolis, Singapore.

2. Department of Pathology and Immunology, Medical School, Centre Médical Universitaire, University of Geneva, Geneva, Switzerland.

3. Platform Technology & Sciences Department, GlaxoSmithKline, Stevenage, United Kingdom.

4. Neuroimmunology Discovery Performance Unit, Neurosciences Therapeutic Area, GlaxoSmithKline, Shanghai, China.

5. Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, King of Prussia, Pennsylvania.

Publisher

Mary Ann Liebert Inc

Subject

Cell Biology,Clinical Biochemistry,Molecular Biology,Physiology,Biochemistry,Cell Biology,Clinical Biochemistry,Molecular Biology,Physiology,Biochemistry

Link

http://www.liebertpub.com/doi/pdf/10.1089/ars.2014.6202

Reference69 articles.

1. Role of NADPH Oxidase in Retinal Vascular Inflammation

2. The NOX toolbox: validating the role of NADPH oxidases in physiology and disease

3. Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement

4. Is Cardiac Hypertrophy in Spontaneously Hypertensive Rats the Cause or the Consequence of Oxidative Stress?

5. p47phox is required for atherosclerotic lesion progression in ApoE–/– mice

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