High-Content Imaging in Human and Rat Hepatocytes Using the Fluorescent Dyes CLF and CMFDA Is Not Specific Enough to Assess BSEP/Bsep and/or MRP2/Mrp2 Inhibition by Cholestatic Drugs-Reference-Cited by-同舟云学术

High-Content Imaging in Human and Rat Hepatocytes Using the Fluorescent Dyes CLF and CMFDA Is Not Specific Enough to Assess BSEP/Bsep and/or MRP2/Mrp2 Inhibition by Cholestatic Drugs

Published:2015-09 Issue:3 Volume:1 Page:198-212
ISSN:2332-1512
Container-title:Applied In Vitro Toxicology
language:en
Short-container-title:Applied In Vitro Toxicology

Author:

Qiu Luping¹,Finley James²,Taimi Mohammed²,Aleo Michael D.²,Strock Christopher³,Gilbert Jonathan³,Qin Shuzhen³,Will Yvonne²

Affiliation:

1. Center for Therapeutic Innovation, Pfizer Global R&D, New York, New York.

2. Drug Safety Research and Development, Global Pfizer R&D, Groton, Connecticut.

3. Cyprotex, Watertown, Massachusetts.

Publisher

Mary Ann Liebert Inc

Subject

Health, Toxicology and Mutagenesis,Medical Laboratory Technology,Toxicology

Link

http://www.liebertpub.com/doi/pdf/10.1089/aivt.2015.0014

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5. In Vitro Inhibition of the Bile Salt Export Pump Correlates with Risk of Cholestatic Drug-Induced Liver Injury in Humans

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