Recombinant Extracellular Matrix Protein Fragments Support Human Embryonic Stem Cell Chondrogenesis
Author:
Affiliation:
1. Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
2. Academic Group—Engineering, Sports and Sciences, The University of Bolton, Bolton, United Kingdom.
Publisher
Mary Ann Liebert Inc
Subject
Biomedical Engineering,Biomaterials,Biochemistry,Bioengineering
Link
https://www.liebertpub.com/doi/pdf/10.1089/ten.tea.2017.0285
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3. Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration.
4. Cartilage contains mixed fibrils of collagen types II, IX, and XI.
5. Ultrastructural localization of collagen types II, IX, and XI in the growth plate of human rib and fetal bovine epiphyseal cartilage: type XI collagen is restricted to thin fibrils.
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