Identification of Pregnane X Receptor Ligands Using Time-Resolved Fluorescence Resonance Energy Transfer and Quantitative High-Throughput Screening-Reference-Cited by-同舟云学术

Identification of Pregnane X Receptor Ligands Using Time-Resolved Fluorescence Resonance Energy Transfer and Quantitative High-Throughput Screening

Published:2009-04 Issue:2 Volume:7 Page:143-169
ISSN:1540-658X
Container-title:ASSAY and Drug Development Technologies
language:en
Short-container-title:ASSAY and Drug Development Technologies

Author:

Shukla Sunita J.¹,Nguyen Dac-Trung¹,MacArthur Ryan¹,Simeonov Anton¹,Frazee William J.²,Hallis Tina M.²,Marks Bryan D.²,Singh Upinder²,Eliason Hildegard C.²,Printen John²,Austin Christopher P.¹,Inglese James¹,Auld Douglas S.¹

Affiliation:

1. NIH Chemical Genomics Center, National Institutes of Health, Bethesda, Maryland.

2. Invitrogen Discovery Assays and Services, Madison, Wisconsin.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Molecular Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/adt.2009.193

Reference42 articles.

1. The Nuclear Pregnane X Receptor: A Key Regulator of Xenobiotic Metabolism

2. The pregnane X receptor: from bench to bedside

3. Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands

4. A Miniaturized Glucocorticoid Receptor Translocation Assay Using Enzymatic Fragment Complementation Evaluated with qHTS

5. Nuclear Pregnane X Receptor and Constitutive Androstane Receptor Regulate Overlapping but Distinct Sets of Genes Involved in Xenobiotic Detoxification

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