Differential activation of human pregnane X receptor PXR by isomeric mono-methylated indoles in intestinal and hepatic in vitro models

Author:

Vyhlídalová Barbora,Bartoňková Iveta,Jiskrová Eva,Li Hao,Mani Sridhar,Dvořák ZdeněkORCID

Funder

Czech Science Foundation

Palacky University

Operational Programme Research, Development and Education - European Regional Development Fund, the Ministry of Education, Youth and Sports of the Czech Republic

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference30 articles.

1. Microbial-derived lithocholic acid and vitamin K2 drive the metabolic maturation of pluripotent stem cells-derived and fetal hepatocytes;Avior;Hepatology,2015

2. Essential oils of culinary herbs and spices activate PXR and induce CYP3A4 in human intestinal and hepatic in vitro models;Bartonkova;Toxicol. Lett.,2018

3. Marine ligands of the pregnane X receptor (PXR): an overview;Carazo;Mar. Drugs,2019

4. Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation;Cho;J. Lipid Res.,2009

5. Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes;Drocourt;Drug Metab. Dispos.,2001

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