An Integrated Multiassay Approach to the Discovery of Small-Molecule N-Type Voltage-Gated Calcium Channel Antagonists
Author:
Affiliation:
1. Analgesics Team, Johnson & Johnson Pharmaceutical Research & Development, Spring House, Pennsylvania.
Publisher
Mary Ann Liebert Inc
Subject
Drug Discovery,Molecular Medicine
Link
http://www.liebertpub.com/doi/pdf/10.1089/adt.2010.0311
Reference27 articles.
1. Targeting chronic and neuropathic pain: The N-type calcium channel comes of age
2. Stimulating the development of mechanism-based, individualized pain therapies
3. Emerging drug discovery strategies for alleviating neuropathic pain
4. Cell-Specific Alternative Splicing Increases Calcium Channel Current Density in the Pain Pathway
5. Autoradiographic localization of calcium channels with [125I]ω-conotoxin in rat brain
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1. Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Cav 2.2) blockers for the treatment of pain;Bioorganic & Medicinal Chemistry Letters;2018-12
2. Opposite Roles in Short-Term Plasticity for N-Type and P/Q-Type Voltage-Dependent Calcium Channels in GABAergic Neuronal Connections in the Rat Cerebral Cortex;The Journal of Neuroscience;2018-09-24
3. Discovery and SAR of a novel series of 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles as N-type calcium channel inhibitors;Bioorganic & Medicinal Chemistry Letters;2014-05
4. Mechanistic Insights Into the Analgesic Efficacy of A-1264087, a Novel Neuronal Ca2+ Channel Blocker That Reduces Nociception in Rat Preclinical Pain Models;The Journal of Pain;2014-04
5. Expression and Pharmacology of Endogenous Cav Channels in SH-SY5Y Human Neuroblastoma Cells;PLoS ONE;2013-03-25
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