Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Cav 2.2) blockers for the treatment of pain-Reference-Cited by-同舟云学术

Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Cav 2.2) blockers for the treatment of pain

Published:2018-12 Issue:23-24 Volume:28 Page:3780-3783
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Wall Mark J.,Subasinghe Nalin L.,Winters Michael P.,Lubin Mary Lou,Finley Michael F.A.,Qin Ning,Brandt Michael R.,Neeper Michael P.,Schneider Craig R.,Colburn Raymond W.,Flores Christopher M.,Sui Zhihua

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference12 articles.

1. Emerging drug discovery strategies for alleviating neuropathic pain

2. Targeting chronic and neuropathic pain: The N-type calcium channel comes of age

3. Cell-Specific Alternative Splicing Increases Calcium Channel Current Density in the Pain Pathway

4. Autoradiographic localization of calcium channels with [125I]ω-conotoxin in rat brain

5. Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel

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