Comparative Analysis of Five Highly Conserved Target Sites Within the HIV-1 RNA for Their Susceptibility to Hammerhead Ribozyme-Mediated CleavageIn VitroandIn Vivo
Author:
Publisher
Mary Ann Liebert Inc
Subject
Pharmacology,Genetics
Link
http://www.liebertpub.com/doi/pdf/10.1089/oli.1.1996.6.229
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1. Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone
2. Multitarget-ribozyme directed to cleave at up to nine highly conserved HIV-1 env RNA regions inhibits HIV-1 replication—potential effectiveness against most presently sequenced HIV-1 isolates
3. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
4. Inhibition of HIV-1 Multiplication in a Human CD4+Lymphocytic Cell Line Expressing Antisense and Sense RNA Molecules Containing HIV-1 Packaging Signal and Rev Response Element(s)
5. Inhibition of HIV-1 replication by ribozymes that show poor activityin vitro
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