A novel gene therapy strategy using secreted multifunctional anti-HIV proteins to confer protection to gene-modified and unmodified target cells

Author:

Falkenhagen A,Ameli M,Asad S,Read S E,Joshi S

Publisher

Springer Science and Business Media LLC

Subject

Genetics,Molecular Biology,Molecular Medicine

Reference88 articles.

1. Joos B, Fischer M, Kuster H, Pillai SK, Wong JK, Boni J et al. HIV rebounds from latently infected cells, rather than from continuing low-level replication. Proc Natl Acad Sci USA 2008; 105: 16725–16730.

2. Nachega JB, Mugavero MJ, Zeier M, Vitoria M, Gallant JE . Treatment simplification in HIV-infected adults as a strategy to prevent toxicity, improve adherence, quality of life and decrease healthcare costs. Patient Prefer Adherence 2011; 5: 357–367.

3. Gaspar HB, Cooray S, Gilmour KC, Parsley KL, Zhang F, Adams S et al. Hematopoietic stem cell gene therapy for adenosine deaminase-deficient severe combined immunodeficiency leads to long-term immunological recovery and metabolic correction. Sci Transl Med 2011; 3: 97ra80.

4. Gaspar HB, Cooray S, Gilmour KC, Parsley KL, Adams S, Howe SJ et al. Long-term persistence of a polyclonal T cell repertoire after gene therapy for X-linked severe combined immunodeficiency. Sci Transl Med 2011; 3: 97ra79.

5. Cartier N, Hacein-Bey-Abina S, Bartholomae CC, Bougneres P, Schmidt M, Kalle CV et al. Lentiviral hematopoietic cell gene therapy for X-linked adrenoleukodystrophy. Methods Enzymol 2012; 507: 187–198.

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