Not Reinventing the Wheel: Applying the 3Rs Concepts to Viral Vector Gene Therapy Biodistribution Studies-Reference-Cited by-同舟云学术

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Not Reinventing the Wheel: Applying the 3Rs Concepts to Viral Vector Gene Therapy Biodistribution Studies

Published:2013-03 Issue:1 Volume:24 Page:1-4
ISSN:2324-8637
Container-title:Human Gene Therapy Clinical Development
language:en
Short-container-title:Human Gene Therapy Clinical Development

Author:

MacLachlan Timothy K.¹,McIntyre Maritza²,Mitrophanous Kyriacos³,Miskin James³,Jolly Douglas J.⁴,Cavagnaro Joy A.⁵

Affiliation:

1. Department of Preclinical Safety, Novartis Institutes for Biomedical Research, Cambridge, MA 02139.

2. ReGenX Biosciences, Washington, DC 20006.

3. Department of Virology, Oxford Biomedica, Oxford OX4 4GA, United Kingdom.

4. Tocagen, San Diego, CA 92109.

5. Access BIO, Boyce, VA 22620.

Publisher

Mary Ann Liebert Inc

Subject

Genetics(clinical)

Link

http://www.liebertpub.com/doi/pdf/10.1089/humc.2013.008

Reference12 articles.

1. AAV Capsid Structure and Cell Interactions

2. Lack of Germline Transmission of Vector Sequences Following Systemic Administration of Recombinant AAV-2 Vector in Males

3. Effect of Administration Route on the Biodistribution and Shedding of Replication-Deficient AAV2: A Qualitative Modelling Approach

4. Gene transfer vector biodistribution: pivotal safety studies in clinical gene therapy development

5. Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector

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1. Regulatory Consideration for the Nonclinical Safety Assessment of Gene Therapies;Human Gene Therapy;2022-09-14

2. Low molecular weight polyethyleneimine modified by 2-aminoimidazole achieving excellent gene transfection efficiency;European Polymer Journal;2020-11

3. An Overview of rAAV Vector Product Development for Gene Therapy;Regenerative Medicine for Degenerative Muscle Diseases;2015-12-19

4. Charting a Clear Path: The ASGCT Standardized Pathways Conference;Molecular Therapy;2014-07

5. Safety profile of recombinant adeno-associated viral vectors: focus on alipogene tiparvovec (Glybera®);Expert Review of Clinical Pharmacology;2013-11-25

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