Effectiveness and Preclinical Safety Profile of Doxycycline to Be Used “Off-Label” to Induce Therapeutic Transgene Expression in a Phase I Clinical Trial for Glioma-Reference-Cited by-同舟云学术

Effectiveness and Preclinical Safety Profile of Doxycycline to Be Used “Off-Label” to Induce Therapeutic Transgene Expression in a Phase I Clinical Trial for Glioma

Published:2013-09 Issue:3 Volume:24 Page:116-126
ISSN:2324-8637
Container-title:Human Gene Therapy Clinical Development
language:en
Short-container-title:Human Gene Therapy Clinical Development

Author:

VanderVeen Nathan¹²,Paran Christopher¹²,Krasinkiewicz Jonathan¹²,Zhao Lili³,Palmer Donna⁴,Hervey-Jumper Shawn¹,Ng Philip⁴,Lowenstein Pedro R.¹²,Castro Maria G.¹²

Affiliation:

1. Department of Neurosurgery, The University of Michigan School of Medicine, Ann Arbor, MI 48109.

2. Department of Cell and Developmental Biology, The University of Michigan School of Medicine, Ann Arbor, MI 48109.

3. Department of Biostatistics, The University of Michigan School of Public Health, Ann Arbor, Michigan 48109.

4. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.

Publisher

Mary Ann Liebert Inc

Subject

Genetics (clinical)

Link

http://www.liebertpub.com/doi/pdf/10.1089/humc.2013.139

Reference35 articles.

1. Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines

2. Inflammatory and Anti-glioma Effects of an Adenovirus Expressing Human Soluble Fms-like Tyrosine Kinase 3 Ligand (hsFlt3L): Treatment with hsFlt3L Inhibits Intracranial Glioma Progression

3. Combined Immunostimulation and Conditional Cytotoxic Gene Therapy Provide Long-term Survival in a Large Glioma Model

4. Effective High-Capacity Gutless Adenoviral Vectors Mediate Transgene Expression in Human Glioma Cells

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