Insight into Thyroid-Stimulating Autoantibody Interaction with the Thyrotropin Receptor N-Terminus Based on Mutagenesis and Re-Evaluation of Ambiguity in This Region of the Receptor Crystal Structure-Reference-Cited by-同舟云学术

Insight into Thyroid-Stimulating Autoantibody Interaction with the Thyrotropin Receptor N-Terminus Based on Mutagenesis and Re-Evaluation of Ambiguity in This Region of the Receptor Crystal Structure

Published:2011-09 Issue:9 Volume:21 Page:1013-1020
ISSN:1050-7256
Container-title:Thyroid
language:en
Short-container-title:Thyroid

Author:

Hamidi Sepehr¹²,Chen Chun-Rong¹²,McLachlan Sandra M.¹²,Rapoport Basil¹²

Affiliation:

1. Thyroid Autoimmune Disease Unit, Cedars-Sinai Research Institute, Los Angeles, California.

2. School of Medicine, University of California—Los Angeles, Los Angeles, California.

Publisher

Mary Ann Liebert Inc

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism

Link

https://www.liebertpub.com/doi/pdf/10.1089/thy.2011.0147

Reference25 articles.

1. Thyrotropin-luteinizing hormone/chorionic gonadotropin receptor extracellular domain chimeras as probes for thyrotropin receptor function.

2. Further characterization of a high affinity thyrotropin binding site on the rat thyrotropin receptor which is an epitope for blocking antibodies from idiopathic myxedema patients but not thyroid stimulating antibodies from Graves' patients

3. Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding

4. Glycoprotein hormone receptors: determinants in leucine-rich repeats responsible for ligand specificity

5. Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

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