In Vitro Metabolic Stabilities and Metabolism of 2′-O-(Methoxyethyl) Partially Modified Phosphorothioate Antisense Oligonucleotides in Preincubated Rat or Human Whole Liver Homogenates-Reference-Cited by-同舟云学术

In Vitro Metabolic Stabilities and Metabolism of 2′-O-(Methoxyethyl) Partially Modified Phosphorothioate Antisense Oligonucleotides in Preincubated Rat or Human Whole Liver Homogenates

Published:2010-12 Issue:6 Volume:20 Page:309-316
ISSN:1545-4576
Container-title:Oligonucleotides
language:en
Short-container-title:Oligonucleotides

Author:

Baek Min-Son¹,Yu Rosie Z.¹,Gaus Hans¹,Grundy John S.¹,Geary Richard S.¹

Affiliation:

1. Pharmacokinetic and Clinical Pharmacology Group, ISIS Pharmaceuticals, Inc., Carlsbad, California.

Publisher

Mary Ann Liebert Inc

Subject

Genetics,Molecular Biology,Molecular Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/oli.2010.0252

Reference33 articles.

1. RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

2. CATTERALL, J.F., and WELKER, N.E. (1980). Purification and Properties of the Bst 1503 Endonuclease in Methods in Enzymology, vol. 65. (Academic Press Inc., Maryland Heights), pp. 167–170.

3. A Phase I Pharmacokinetic and Pharmacodynamic Study of OGX-011, a 2′-Methoxyethyl Antisense Oligonucleotide to Clusterin, in Patients With Localized Prostate Cancer

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