In Vitro Metabolic Stabilities and Metabolism of 2′-O-(Methoxyethyl) Partially Modified Phosphorothioate Antisense Oligonucleotides in Preincubated Rat or Human Whole Liver Homogenates
Author:
Affiliation:
1. Pharmacokinetic and Clinical Pharmacology Group, ISIS Pharmaceuticals, Inc., Carlsbad, California.
Publisher
Mary Ann Liebert Inc
Subject
Genetics,Molecular Biology,Molecular Medicine
Link
http://www.liebertpub.com/doi/pdf/10.1089/oli.2010.0252
Reference33 articles.
1. RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform
2. CATTERALL, J.F., and WELKER, N.E. (1980). Purification and Properties of the Bst 1503 Endonuclease in Methods in Enzymology, vol. 65. (Academic Press Inc., Maryland Heights), pp. 167–170.
3. A Phase I Pharmacokinetic and Pharmacodynamic Study of OGX-011, a 2′-Methoxyethyl Antisense Oligonucleotide to Clusterin, in Patients With Localized Prostate Cancer
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