An Automated Electrophysiology Serum Shift Assay for KVChannels-Reference-Cited by-同舟云学术

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An Automated Electrophysiology Serum Shift Assay for KVChannels

Published:2008-04 Issue:2 Volume:6 Page:243-253
ISSN:1540-658X
Container-title:ASSAY and Drug Development Technologies
language:en
Short-container-title:ASSAY and Drug Development Technologies

Author:

Ratliff Kevin S.¹,Petrov Aleksandr²,Eiermann George J.²,Deng Qiaolin³,Green Mitchell D.⁴,Kaczorowski Gregory J.¹,McManus Owen B.¹,Herrington James¹

Affiliation:

1. Department of Ion Channels, Merck Research Laboratories, Rahway, NJ.

2. Department of Pharmacology, Merck Research Laboratories, Rahway, NJ.

3. Department of Molecular Systems, Merck Research Laboratories, Rahway, NJ.

4. Department of Preclinical DMPK, Merck Research Laboratories, Rahway, NJ.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Molecular Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/adt.2008.128

Reference19 articles.

1. The importance of plasma protein binding in drug discovery

2. Protein binding of human immunodeficiency virus protease inhibitor KNI-272 and alteration of its in vitro antiretroviral activity in the presence of high concentrations of proteins

3. Human serum alpha 1 acid glycoprotein reduces uptake, intracellular concentration, and antiviral activity of A-80987, an inhibitor of the human immunodeficiency virus type 1 protease

4. Phase I/II Study of the Toxicity, Pharmacokinetics, and Activity of the HIV Protease Inhibitor SC-52151

5. DuP 532, an angiotensin II receptor antagonist: First administration and comparison with losartan*

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Ion Channels as Medicinal Targets of Biological Toxins: The Impact of Automated Patch-Clamp Electrophysiology;Current Topics in Medicinal Chemistry;2015-03-10

2. The Role of Voltage-Gated Potassium Channels Kv2.1 and Kv2.2 in the Regulation of Insulin and Somatostatin Release from Pancreatic Islets;Journal of Pharmacology and Experimental Therapeutics;2012-11-16

3. Ion channel drug discovery: challenges and future directions;Future Medicinal Chemistry;2012-04

4. Selective, Direct Activation of High-Conductance, Calcium-Activated Potassium Channels Causes Smooth Muscle Relaxation;Molecular Pharmacology;2012-01-12

5. Identification of Novel and Selective KV2 Channel Inhibitors;Molecular Pharmacology;2011-09-26

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