Site-Specific PEGylation Enhances the Pharmacokinetic Properties and Antitumor Activity of Interferon Beta-1b
Author:
Affiliation:
1. Bolder BioTechnology, Inc., Boulder, Colorado.
2. Premier Laboratory, LLC, Longmont, Colorado.
Publisher
Mary Ann Liebert Inc
Subject
Virology,Cell Biology,Immunology
Link
http://www.liebertpub.com/doi/pdf/10.1089/jir.2012.0148
Reference39 articles.
1. Rational Design of a Potent, Long-Lasting Form of Interferon: A 40 kDa Branched Polyethylene Glycol-Conjugated Interferon α-2a for the Treatment of Hepatitis C
2. N-Terminally PEGylated Human Interferon-β-1a with Improved Pharmacokinetic Properties and in Vivo Efficacy in a Melanoma Angiogenesis Model
3. Structure−Function Engineering of Interferon-β-1b for Improving Stability, Solubility, Potency, Immunogenicity, and Pharmacokinetic Properties by Site-Selective Mono-PEGylation
4. Enhanced Circulating Half-Life and Antitumor Activity of a Site-Specific Pegylated Interferon-α Protein Therapeutic
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