Minocycline Restores sAPPα Levels and Reduces the Late Histopathological Consequences of Traumatic Brain Injury in Mice
Author:
Affiliation:
1. Laboratoire de Pharmacologie de la Circulation Cérébrale (EA 4475), Université Paris Descartes, Sorbonne Paris Cité, Faculté des Sciences Pharmaceutiques et Biologiques, Paris, France.
Publisher
Mary Ann Liebert Inc
Subject
Clinical Neurology
Link
http://www.liebertpub.com/doi/pdf/10.1089/neu.2010.1738
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1. Minocycline chelates Ca2+, binds to membranes, and depolarizes mitochondria by formation of Ca2+-dependent ion channels
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4. Quantitative structural changes in white and gray matter 1 year following traumatic brain injury in rats
5. Transient neuroprotection by minocycline following traumatic brain injury is associated with attenuated microglial activation but no changes in cell apoptosis or neutrophil infiltration
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