A Novel High-Throughput Screening Platform Reveals an Optimized Cytokine Formulation for Human Hematopoietic Progenitor Cell Expansion-Reference-Cited by-同舟云学术

A Novel High-Throughput Screening Platform Reveals an Optimized Cytokine Formulation for Human Hematopoietic Progenitor Cell Expansion

Published:2016-11-15 Issue:22 Volume:25 Page:1709-1720
ISSN:1547-3287
Container-title:Stem Cells and Development
language:en
Short-container-title:Stem Cells and Development

Author:

Tarunina Marina¹,Hernandez Diana¹,Kronsteiner-Dobramysl Barbara²³,Pratt Philip⁴,Watson Thomas¹,Hua Peng²³,Gullo Francesca²³,van der Garde Mark²³,Zhang Youyi²³,Hook Lilian¹,Choo Yen¹,Watt Suzanne M.²³

Affiliation:

1. Plasticell Ltd., Stevenage Bioscience Catalyst, Stevenage, United Kingdom

2. Stem Cell Research, Nuffield Division of Clinical Laboratory Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.

3. Stem Cell Research, NHS Blood and Transplant, Radcliffe Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom.

4. Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, South Kensington, United Kingdom.

Publisher

Mary Ann Liebert Inc

Subject

Cell Biology,Developmental Biology,Hematology

Link

https://www.liebertpub.com/doi/pdf/10.1089/scd.2016.0216

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1. Enforced fucosylation of neonatal CD34+ cells generates selectin ligands that enhance the initial interactions with microvessels but not homing to bone marrow

2. Overexpression of CXCR4 on human CD34+ progenitors increases their proliferation, migration, and NOD/SCID repopulation

3. Short-Term Culture of Umbilical Cord Blood–Derived CD34 Cells Enhances Engraftment Into NOD/SCID Mice Through Increased CXCR4 Expression