Identification and Optimization of a Minor Allele-Specific siRNA to Prevent PNPLA3 I148M-Driven Nonalcoholic Fatty Liver Disease-Reference-Cited by-同舟云学术

Identification and Optimization of a Minor Allele-Specific siRNA to Prevent PNPLA3 I148M-Driven Nonalcoholic Fatty Liver Disease

Published:2021-10-01 Issue:5 Volume:31 Page:324-340
ISSN:2159-3337
Container-title:Nucleic Acid Therapeutics
language:en
Short-container-title:Nucleic Acid Therapeutics

Author:

Murray Justin K.¹,Long Jason¹,Liu Lei²,Singh Shivani²,Pruitt Danielle²,Ollmann Michael³,Swearingen Elissa³,Hardy Miki³,Homann Oliver³,Wu Bin¹,Holder Jerry Ryan¹,Sham Kelvin¹,Herberich Brad¹,Lo Mei-Chu⁴,Dou Hui⁴,Shkumatov Artem⁵,Florio Monica⁶,Rulifson Ingrid C.²^ORCID

Affiliation:

1. Therapeutic Discovery, Amgen Research, Thousand Oaks, California, USA.

2. Cardiometabolic Disorders, Amgen Research, South San Francisco, California, USA.

3. Genome Analysis Unit, Amgen Research, South San Francisco, California, USA.

4. Therapeutic Discovery, Amgen Research, South San Francisco, California, USA.

5. Translational Safety and Bioanalytical Sciences, Amgen Research, South San Francisco, California, USA.

6. Cardiometabolic Disorders, Amgen Research, Thousand Oaks, California, USA.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Genetics,Molecular Biology,Molecular Medicine,Biochemistry

Link

https://www.liebertpub.com/doi/pdf/10.1089/nat.2021.0026

Reference75 articles.

1. Effect of the patatin‐like phospholipase domain containing 3 gene ( PNPLA3 ) I148M polymorphism on the risk and severity of nonalcoholic fatty liver disease and metabolic syndromes: A meta‐analysis of paediatric and adolescent individuals

2. Leveraging Human Genetics to Identify Potential New Treatments for Fatty Liver Disease

3. PNPLA3 gene in liver diseases

4. Association Between Patatin-Like Phospholipase Domain Containing 3 Gene (PNPLA3) Polymorphisms and Nonalcoholic Fatty Liver Disease: A HuGE Review and Meta-Analysis

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