Recent Advances in Immune Regulation by Targeting Dendritic Cells using Small Interfering RNAs-Reference-Cited by-同舟云学术

Recent Advances in Immune Regulation by Targeting Dendritic Cells using Small Interfering RNAs

Published:2024-06-07 Issue: Volume:24 Page:
ISSN:1566-5240
Container-title:Current Molecular Medicine
language:en
Short-container-title:CMM

Author:

Shahverdi Mahshid¹,Alamdari-Palangi Vahab²,Alipour Shiva³⁴,Ghaffari Jolfayi Amir⁵,Masoumi Javad³,Aghebati-Maleki Leili³,Rostamlou Arman⁶,Baradaran Behzad³

Affiliation:

1. Department of Medical Biotechnology, Arak University of Medical Sciences, Arak, Iran

2. Department of Molecular Medicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran

3. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

4. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

5. Cardiovascular Research Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran

6. Department of Medical Biology, Faculty of Medicine, University of EGE, IZMIR, Turkey

Abstract

Abstract: Gene silencing through RNA interference (RNAi) technology has provided forceful therapeutic modalities to specific knockdown of the genes' expression related to diseases. Small interfering RNAs (siRNAs) can start a process that specifically degrades and silences the expression of cognate mRNAs. These RNA interference processes could effectively adjust many biological processes, including immune responses. Dendritic cells (DCs) are specialist antigen-presenting cells with potent functions in regulating innate and adaptive immunity. SiRNAs performed vital roles in coordinating immune processes mediated by DCs. This review describes the findings that shed light on the significance of siRNAs in DC immune regulation and highlight their potential applications for improving DC-based immunotherapies

Publisher

Bentham Science Publishers Ltd.