Adeno-Associated Virus Serotype 8 Gene Therapy Leads to Significant Lowering of Plasma Cholesterol Levels in Humanized Mouse Models of Homozygous and Heterozygous Familial Hypercholesterolemia-Reference-Cited by-同舟云学术

Adeno-Associated Virus Serotype 8 Gene Therapy Leads to Significant Lowering of Plasma Cholesterol Levels in Humanized Mouse Models of Homozygous and Heterozygous Familial Hypercholesterolemia

Published:2013-01 Issue:1 Volume:24 Page:19-26
ISSN:1043-0342
Container-title:Human Gene Therapy
language:en
Short-container-title:Human Gene Therapy

Author:

Kassim Sadik H.¹,Li Hui²,Bell Peter¹,Somanathan Suryanarayan¹,Lagor William²,Jacobs Frank¹,Billheimer Jeffrey²,Wilson James M.¹,Rader Daniel J.²

Affiliation:

1. Gene Therapy Program, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

2. Cardiovascular Institute and Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

Publisher

Mary Ann Liebert Inc

Subject

Genetics,Molecular Biology,Molecular Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/hum.2012.108

Reference31 articles.

1. Effect of intensive plasmapheresis on the plasma cholesterol concentration with familial hypercholesterolemia

2. A Receptor-Mediated Pathway for Cholesterol Homeostasis

3. Mouse Models of Atherosclerosis

4. The LDL Receptor Defect in Familial Hypercholesterolemia: Implications for Pathogenesis and Therapy

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