Cation Coordination Alters the Conformation of a Thrombin-Binding G-Quadruplex DNA Aptamer That Affects Inhibition of Thrombin
Author:
Affiliation:
1. Chemistry Department, Lomonosov Moscow State University, Moscow, Russia.
2. Belozersky Institute of Physical-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
Publisher
Mary Ann Liebert Inc
Subject
Drug Discovery,Genetics,Molecular Biology,Molecular Medicine,Biochemistry
Link
http://www.liebertpub.com/doi/pdf/10.1089/nat.2016.0606
Reference22 articles.
1. G-quadruplex DNA Aptamers and their Ligands: Structure, Function and Application
2. Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics
3. Nucleic Acid Aptamers: An Emerging Tool for Biotechnology and Biomedical Sensing
4. Polyvalent nucleic acid aptamers and modulation of their activity: a focus on the thrombin binding aptamer
5. A novel method of screening thrombin-inhibiting DNA aptamers using an evolution-mimicking algorithm
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