Evolution of a bispecific G-quadruplex-forming circular aptamer to block IL-6/sIL-6R interaction for inflammation inhibition-Reference-Cited by-同舟云学术

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Evolution of a bispecific G-quadruplex-forming circular aptamer to block IL-6/sIL-6R interaction for inflammation inhibition

Published:2024 Issue:32 Volume:15 Page:13011-13020
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Yao Lili¹,Wang Lei¹,Liu Shuai¹,Qu Hao¹^ORCID,Mao Yu¹,Li Yingfu²^ORCID,Zheng Lei¹^ORCID

Affiliation:

1. School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China

2. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton L8S4K1, Canada

Abstract

We report a circular DNA aptamer isolated from a synthetic DNA library to bind both IL-6 and sIL-6R with nanomolar affinities. This aptamer can effectively block the IL-6/sIL-6R interaction and significantly inhibit cell inflammation.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Natural Science Foundation of Anhui Province

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC02183E

Reference52 articles.

1. The pro- and anti-inflammatory properties of the cytokine interleukin-6

2. Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer

3. Plasticity and cross-talk of Interleukin 6-type cytokines

4. The Soluble Interleukin 6 Receptor: Advanced Therapeutic Options in Inflammation

5. Chemically Modified DNA Aptamers Bind Interleukin-6 with High Affinity and Inhibit Signaling by Blocking Its Interaction with Interleukin-6 Receptor

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