Antihelminthic Benzimidazoles Are Novel HIF Activators That Prevent Oxidative Neuronal Death via Binding to Tubulin-Reference-Cited by-同舟云学术

Antihelminthic Benzimidazoles Are Novel HIF Activators That Prevent Oxidative Neuronal Death via Binding to Tubulin

Published:2015-01-10 Issue:2 Volume:22 Page:121-134
ISSN:1523-0864
Container-title:Antioxidants & Redox Signaling
language:en
Short-container-title:Antioxidants & Redox Signaling

Author:

Aleyasin Hossein¹²,Karuppagounder Saravanan S.¹²,Kumar Amit¹²,Sleiman Sama¹²,Basso Manuela¹²,Ma Thong¹²,Siddiq Ambreena¹²,Chinta Shankar J.³,Brochier Camille¹²,Langley Brett¹²,Haskew-Layton Renee¹²,Bane Susan L.⁴,Riggins Gregory J.⁵,Gazaryan Irina¹²,Starkov Anatoly A.²,Andersen Julie K.³,Ratan Rajiv R.¹²

Affiliation:

1. Burke-Cornell Medical Research Institute, White Plains, New York.

2. Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York.

3. Buck Institute for Age Research, Novato, California.

4. Department of Chemistry, State University of New York at Binghamton, Binghamton, New York.

5. Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Publisher

Mary Ann Liebert Inc

Subject

Cell Biology,Clinical Biochemistry,Molecular Biology,Physiology,Biochemistry,Cell Biology,Clinical Biochemistry,Molecular Biology,Physiology,Biochemistry

Link

http://www.liebertpub.com/doi/pdf/10.1089/ars.2013.5595

Reference61 articles.

1. Prosurvival and Prodeath Effects of Hypoxia-inducible Factor-1α Stabilization in a Murine Hippocampal Cell Line

2. SEPT9_v1 Up-regulates Hypoxia-inducible Factor 1 by Preventing Its RACK1-mediated Degradation

3. Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse

4. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

5. Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme

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