Strategies for optimization of the CRISPR-based genome editing system for enhanced editing specificity
Author:
Affiliation:
1. Guangdong Pharmaceutical University, 71237, Guangzhou, Guangdong, China;
2. Guangdong Pharmaceutical University, 71237, School of Biosciences and Biopharmaceutics , 28 E. Rd outside the City of Guangzhou University, Guangzhou, China, 510006, ;
Publisher
Mary Ann Liebert Inc
Subject
Genetics,Molecular Biology,Molecular Medicine
Link
https://www.liebertpub.com/doi/pdf/10.1089/hum.2021.283
Reference67 articles.
1. A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
2. Base editing: precision chemistry on the genome and transcriptome of living cells
3. CRISPR/Cas-Mediated Base Editing: Technical Considerations and Practical Applications
4. Cas9 activates the p53 pathway and selects for p53-inactivating mutations
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1. Hitchhiking of Cas9 with nucleus-localized proteins impairs its controllability and leads to efficient genome editing of NLS-free Cas9;Molecular Therapy;2024-04
2. Improvements of nuclease and nickase gene modification techniques for the treatment of genetic diseases;Frontiers in Genome Editing;2022-07-26
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