Biodistribution and Tolerability of AAV-PHP.B-CBh-SMN1 in Wistar Han Rats and Cynomolgus Macaques Reveal Different Toxicologic Profiles-Reference-Cited by-同舟云学术

Biodistribution and Tolerability of AAV-PHP.B-CBh-SMN1 in Wistar Han Rats and Cynomolgus Macaques Reveal Different Toxicologic Profiles

Published:2021-12-21 Issue: Volume: Page:
ISSN:1043-0342
Container-title:Human Gene Therapy
language:en
Short-container-title:Human Gene Therapy

Author:

PALAZZI Xavier¹,Pardo Ingrid²,Sirivelu Madhu³,Newman Leah²,Kumpf Steven²,Qian Jessie²,Franks Tania²,Lopes Sarah²,Liu June²,Monarski Laura²,Casinghino Sandra²,Ritenour Casey²,Ritenour Hayley²,Dubois Christopher²,Olson Jennifer²,Graves John²,Alexander Kristin²,Coskran Timothy²,Lanz Thomas A²,Brady Joseph³,McCarty Douglas³,Somanathan Suryanarayan³,Whiteley Laurence³

Affiliation:

1. Pfizer Global Research and Development, 105623, 1, Eastern Point Road, Groton, Connecticut, United States, 06340;

2. Pfizer Global Research and Development, 105623, Groton, Connecticut, United States;

3. Pfizer Worldwide Research Development and Medicine, Drug Safety Research and Development, Cambridge, Massachusetts, United States;

Publisher

Mary Ann Liebert Inc

Subject

Genetics,Molecular Biology,Molecular Medicine

Link

https://www.liebertpub.com/doi/pdf/10.1089/hum.2021.116

Reference19 articles.

1. New Recombinant Serotypes of AAV Vectors