Rapid, Simple, and Versatile Manufacturing of Recombinant Adeno-Associated Viral Vectors at Scale-Reference-Cited by-同舟云学术

Rapid, Simple, and Versatile Manufacturing of Recombinant Adeno-Associated Viral Vectors at Scale

Published:2010-10 Issue:10 Volume:21 Page:1259-1271
ISSN:1043-0342
Container-title:Human Gene Therapy
language:en
Short-container-title:Human Gene Therapy

Author:

Lock Martin¹,Alvira Mauricio¹,Vandenberghe Luk H.¹,Samanta Arabinda¹,Toelen Jaan²,Debyser Zeger²,Wilson James M.¹

Affiliation:

1. Gene Therapy Program, Department of Pathology and Laboratory Medicine, Division of Transfusion Medicine, University of Pennsylvania, Philadelphia, PA 19104.

2. Laboratory of Molecular Virology and Gene Therapy, Division of Molecular Medicine, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.

Publisher

Mary Ann Liebert Inc

Subject

Genetics,Molecular Biology,Molecular Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/hum.2010.055

Reference34 articles.

1. Isolation of Highly Infectious and Pure Adeno-Associated Virus Type 2 Vectors with a Single-Step Gravity-Flow Column

2. Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy

3. A Versatile and Scalable Two-Step Ion-Exchange Chromatography Process for the Purification of Recombinant Adeno-associated Virus Serotypes-2 and -5

4. Large-Scale Adeno-Associated Viral Vector Production Using a Herpesvirus-Based System Enables Manufacturing for Clinical Studies

5. Purification of recombinant adeno-associated virus type 8 vectors by ion exchange chromatography generates clinical grade vector stock

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