Development of a Simple and Robust Assay to Screen for Inhibitors of Sphingosine Kinases
Author:
Affiliation:
1. Discovery Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
2. Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Osaka, Japan.
3. Proteros Biostructures GmbH, Martinsried, Germany.
Publisher
Mary Ann Liebert Inc
Subject
Drug Discovery,Molecular Medicine
Link
http://www.liebertpub.com/doi/pdf/10.1089/adt.2006.049
Reference27 articles.
1. Sphingosine Kinase: Biochemical and Cellular Regulation and Role in Disease
2. Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase
3. Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform
4. Sphingosine-1-phosphate: an enigmatic signalling lipid
5. Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors
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2. Structure and catalytic function of sphingosine kinases: Analysis by site-directed mutagenesis and enzyme kinetics;Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids;2013-01
3. A rapid assay for assessment of sphingosine kinase inhibitors and substrates;Analytical Biochemistry;2011-04
4. Evaluating the Utility of a Bioluminescent ADP-Detecting Assay for Lipid Kinases;ASSAY and Drug Development Technologies;2009-12
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