Assessment of the Effects of 2′-Methoxyethyl Antisense Oligonucleotides on Platelet Count in Cynomolgus Nonhuman Primates
Author:
Affiliation:
1. Development, IONIS Pharmaceuticals, Carlsbad, California.
Publisher
Mary Ann Liebert Inc
Subject
Drug Discovery,Genetics,Molecular Biology,Molecular Medicine,Biochemistry
Link
http://www.liebertpub.com/doi/pdf/10.1089/nat.2017.0666
Reference23 articles.
1. Overview of the Nonclinical Development Strategies and Class-Effects of Oligonucleotide-Based Therapeutics
2. Predictive Dose-Based Estimation of Systemic Exposure Multiples in Mouse and Monkey Relative to Human for Antisense Oligonucleotides With 2′-O-(2-Methoxyethyl) Modifications
3. Mechanistic Understanding for the Greater Sensitivity of Monkeys to Antisense Oligonucleotide–Mediated Complement Activation Compared with Humans
4. CpG and Non-CpG Oligodeoxynucleotides Induce Differential Proinflammatory Gene Expression Profiles in Liver and Peripheral Blood Leukocytes in Mice
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1. Complement C3d/C4d Deposition on Platelets Correlates with 2′-O-Methoxyethyl Antisense Oligonucleotide-Induced Thrombocytopenia in Monkeys;Nucleic Acid Therapeutics;2023-06-01
2. Platelet Activation by Antisense Oligonucleotides (ASOs) in the Göttingen Minipig, including an Evaluation of Glycoprotein VI (GPVI) and Platelet Factor 4 (PF4) Ontogeny;Pharmaceutics;2023-03-31
3. Post-transcriptional control of haemostatic genes: mechanisms and emerging therapeutic concepts in thrombo-inflammatory disorders;Cardiovascular Research;2023-03-21
4. Considerations in the Preclinical Assessment of the Safety of Antisense Oligonucleotides;Nucleic Acid Therapeutics;2023-02-01
5. Assessment of the Immunogenicity Potential for Oligonucleotide-Based Drugs;Nucleic Acid Therapeutics;2022-10-01
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