Predictive Dose-Based Estimation of Systemic Exposure Multiples in Mouse and Monkey Relative to Human for Antisense Oligonucleotides With 2′-O-(2-Methoxyethyl) Modifications

Author:

Yu Rosie Z,Grundy John S,Henry Scott P,Kim Tae-Won,Norris Daniel A,Burkey Jennifer,Wang Yanfeng,Vick Andrew,Geary Richard S

Publisher

Elsevier BV

Subject

Drug Discovery,Molecular Medicine

Reference20 articles.

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2. Synovial Biomarker Study of ISIS 104838, An Antisense Oligodeoxynucleotide Targeting TNF-alpha, in Rheumatoid Arthritis. 67th Annual Meeting of the American College of Rheumatology (ACR): Orlando, FL;Wei,2003

3. New Targets for Glycemic Control Protein-Tyrosine-Phosphatase-1B Antisense Inhibitor. the American Diabetes Association's 65th Annual Meeting: San Diego, CA;Kjems,2005

4. mRNA as a therapeutic target in lung disease;Jones;Drug Des Rev,2005

5. A phase I study of OGX-011, a 2’-methoxyethyl phosphorothioate antisense to clusterin, in combination with docetaxel in patients with advanced cancer;Chi;Clin Cancer Res,2008

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