Intracerebroventricular Administration of a 2′-O-Methyl Phosphorothioate Antisense Oligonucleotide Results in Activation of the Innate Immune System in Mouse Brain-Reference-Cited by-同舟云学术

Intracerebroventricular Administration of a 2′-O-Methyl Phosphorothioate Antisense Oligonucleotide Results in Activation of the Innate Immune System in Mouse Brain

Published:2018-04 Issue:2 Volume:28 Page:63-73
ISSN:2159-3337
Container-title:Nucleic Acid Therapeutics
language:en
Short-container-title:Nucleic Acid Therapeutics

Author:

Toonen Lodewijk J.A.¹,Casaca-Carreira João²³⁴⁵,Pellisé-Tintoré Maria²⁶,Mei Hailiang⁷,Temel Yasin²³,Jahanshahi Ali²³,van Roon-Mom Willeke M.C.¹

Affiliation:

1. Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.

2. Department of Neurosurgery, Maastricht University Medical Center, Maastricht, the Netherlands.

3. European Graduate School of Neuroscience (EURON), Maastricht, the Netherlands.

4. Department of Physiotherapy, Portuguese Red Cross Health School, Lisbon, Portugal.

5. Department of Physiotherapy, School of Health Care, Setubal Polytechnic Institute, Setubal, Portugal.

6. Department of Medical Science, Faculty of Medicine, University of Girona (UdG), Girona, Spain.

7. Sequencing Analysis Support Core, Leiden University Medical Center, Leiden, the Netherlands.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Genetics,Molecular Biology,Molecular Medicine,Biochemistry

Link

http://www.liebertpub.com/doi/pdf/10.1089/nat.2017.0705

Reference76 articles.

1. Oligonucleotide Therapies: The Past and the Present

2. The chemical evolution of oligonucleotide therapies of clinical utility

3. Antisense oligonucleotides in therapy for neurodegenerative disorders

4. Distribution and Penetration of Intracerebroventricularly Administered 2′OMePS Oligonucleotide in the Mouse Brain

5. The delivery of therapeutic oligonucleotides

Cited by 24 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Therapeutically targeting the classical complement pathway with antisense oligonucleotides in Alzheimer’s disease;2024-08-26

2. Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2′,4′-BNA/LNA with 9-(aminoethoxy)phenoxazine;Molecular Therapy - Nucleic Acids;2024-03

3. Biodistribution of Radioactively Labeled Splice Modulating Antisense Oligonucleotides After Intracerebroventricular and Intrathecal Injection in Mice;Nucleic Acid Therapeutics;2024-02-01

4. General and Specific Cytotoxicity of Chimeric Antisense Oligonucleotides in Bacterial Cells and Human Cell Lines;Antibiotics;2024-01-26

5. Antisense oligonucleotide-mediated disruption of HTT caspase-6 cleavage site ameliorates the phenotype of YAC128 Huntington disease mice;Neurobiology of Disease;2024-01