Rationally Designed Base Editors for Precise Editing of the Sickle Cell Disease Mutation
Author:
Affiliation:
1. Beam Therapeutics, Cambridge, MA, USA.
Publisher
Mary Ann Liebert Inc
Subject
Genetics,Biotechnology
Link
https://www.liebertpub.com/doi/pdf/10.1089/crispr.2020.0144
Reference30 articles.
1. Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
2. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
3. DNA capture by a CRISPR-Cas9–guided adenine base editor
4. An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities
5. Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors
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