Obesity-Induced Regulator of Calcineurin 1 Overexpression Leads to β-Cell Failure Through Mitophagy Pathway Inhibition

Author:

Li Xujun1,Chan Lawrence W.C.2,Li Xianyu3,Liu Chunyan1,Yang Guohua4,Gao Jianfeng1,Dai Ming1,Wang Yunxin5,Xie Zhiwen6,Liu Junli7,Zhou Fuling8,Zheng Tian9,Feng Du10,Guo Shaodong11,Li Haojie12,Sun Kai13,Yang Sijun1

Affiliation:

1. ABSL-3 Laboratory at the Center for Animal Experiment, Institute of Animal Model for Human Disease, Wuhan University School of Medicine, Wuhan, People's Republic of China.

2. Department of Health Technology and Informatics, Hong Kong Polytechnic University, Hong Kong, Hong Kong.

3. Department of Pathophysiology, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, People's Republic of China.

4. Demonstration Center for Experimental Basic Medicine Education, School of Basic Medical Science, Wuhan University, Wuhan, People's Republic of China.

5. School of Medical Technology, Xuzhou Medical University, Xuzhou, People's Republic of China.

6. School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

7. Shanghai Diabetes Research Institute, Shanghai JiaoTong University Affiliated 6th People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, People's Republic of China.

8. Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.

9. Department of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.

10. Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, People's Republic of China.

11. Department of Nutrition and Food Science, Texas A&M University, College Station, Texas.

12. Shanghai Center for Plant Stress Biology, Chinese Academy of Sciences, Shanghai, People's Republic of China.

13. Center for Metabolic and Degenerative Diseases, Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas.

Publisher

Mary Ann Liebert Inc

Subject

Cell Biology,Clinical Biochemistry,Molecular Biology,Physiology,Biochemistry,Cell Biology,Clinical Biochemistry,Molecular Biology,Physiology,Biochemistry

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