A Flexible Multiplatform Bioanalytical Strategy for Measurement of Total Circulating Shed Target Receptors: Application to Soluble B Cell Maturation Antigen Levels in the Presence of a Bispecific Antibody Drug-Reference-Cited by-同舟云学术

A Flexible Multiplatform Bioanalytical Strategy for Measurement of Total Circulating Shed Target Receptors: Application to Soluble B Cell Maturation Antigen Levels in the Presence of a Bispecific Antibody Drug

Published:2021-01-01 Issue:1 Volume:19 Page:17-26
ISSN:1540-658X
Container-title:ASSAY and Drug Development Technologies
language:en
Short-container-title:ASSAY and Drug Development Technologies

Author:

Stauffer Angela¹,Ray Chad²,Hall Michael¹

Affiliation:

1. Biomedicine Design, Pfizer Worldwide Research, Development, and Medical, San Diego, California, USA.

2. Zoetis Incorporated, Fort Collins, Colorado, USA.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Molecular Medicine

Link

https://www.liebertpub.com/doi/pdf/10.1089/adt.2020.1024

Reference17 articles.

1. Molecular Pathways: Receptor Ectodomain Shedding in Treatment, Resistance, and Monitoring of Cancer

2. Impact of Shed/Soluble targets on the PK/PD of approved therapeutic monoclonal antibodies

3. Free circulating soluble CD52 as a tumor marker in chronic lymphocytic leukemia and its implication in therapy with anti-CD52 antibodies

4. Circulating CD20 and CD52 in patients with non-Hodgkin's lymphoma or Hodgkin's disease

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