Impact of Shed/Soluble targets on the PK/PD of approved therapeutic monoclonal antibodies
Author:
Funder
Genentech, Inc.
Publisher
Informa UK Limited
Subject
Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics,General Medicine
Link
http://www.tandfonline.com/doi/pdf/10.1080/17512433.2016.1243055
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1. Population pharmacokinetics of trastuzumab emtansine (T-DM1), a HER2-targeted antibody–drug conjugate, in patients with HER2-positive metastatic breast cancer: clinical implications of the effect of covariates
2. A model-based meta-analysis of monoclonal antibody pharmacokinetics to guide optimal first-in-human study design
3. When Assay Format Matters: a Case Study on the Evaluation of Three Assay Formats to Support a Clinical Pharmacokinetic Study
4. Biodistribution Mechanisms of Therapeutic Monoclonal Antibodies in Health and Disease
5. Mechanistic Pharmacokinetic/Target Engagement/Pharmacodynamic (PK/TE/PD) Modeling in Deciphering Interplay Between a Monoclonal Antibody and Its Soluble Target in Cynomolgus Monkeys
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