Mechanistic Pharmacokinetic/Target Engagement/Pharmacodynamic (PK/TE/PD) Modeling in Deciphering Interplay Between a Monoclonal Antibody and Its Soluble Target in Cynomolgus Monkeys-Reference-Cited by-同舟云学术

Mechanistic Pharmacokinetic/Target Engagement/Pharmacodynamic (PK/TE/PD) Modeling in Deciphering Interplay Between a Monoclonal Antibody and Its Soluble Target in Cynomolgus Monkeys

Published:2013-11-28 Issue:1 Volume:16 Page:129-139
ISSN:1550-7416
Container-title:The AAPS Journal
language:en
Short-container-title:AAPS J

Author:

Wang Weirong,Wang Xiaofeng,Doddareddy Rajitha,Fink Damien,McIntosh Thomas,Davis Hugh M.,Zhou Honghui

Publisher

Springer Science and Business Media LLC

Subject

Pharmaceutical Science

Link

http://link.springer.com/content/pdf/10.1208/s12248-013-9545-8.pdf

Reference38 articles.

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3. Lee JW, Kelley M, King LE, Yang J, Salimi-Moosavi H, Tang MT, et al. Bioanalytical approaches to quantify “total” and “free” therapeutic antibodies and their targets: technical challenges and PK/PD applications over the course of drug development. AAPS J. 2011;13:99–110.

4. Davda JP, Hansen RJ. Properties of a general PK/PD model of antibody–ligand interactions for therapeutic antibodies that bind to soluble endogenous targets. MAbs. 2010;2:576–88.

5. Tang C, Prueksaritanont T. Theoretical analysis of interplay of therapeutic protein drug and circulating soluble target: temporal profiles of ‘free’ and ‘total’ drug and target. Pharm Res. 2011;28:2447–57.

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