Optimizing Promoters for Recombinant Adeno-Associated Virus-Mediated Gene Expression in the Peripheral and Central Nervous System Using Self-Complementary Vectors-Reference-Cited by-同舟云学术

Optimizing Promoters for Recombinant Adeno-Associated Virus-Mediated Gene Expression in the Peripheral and Central Nervous System Using Self-Complementary Vectors

Published:2011-09 Issue:9 Volume:22 Page:1143-1153
ISSN:1043-0342
Container-title:Human Gene Therapy
language:en
Short-container-title:Human Gene Therapy

Author:

Gray Steven J.¹,Foti Stacey B.¹,Schwartz Joel W.²³,Bachaboina Lavanya¹,Taylor-Blake Bonnie⁴,Coleman Jennifer⁴,Ehlers Michael D.²,Zylka Mark J.⁴,McCown Thomas J.¹⁵⁶,Samulski R. Jude¹⁷

Affiliation:

1. Gene Therapy Center, University of North Carolina, Chapel Hill, NC 27599.

2. Department of Neurobiology, Duke University Medical Center, Durham, NC 27710.

3. David H. Murdock Research Institute, Kannapolis, NC 28081.

4. Department of Cell and Molecular Physiology, UNC Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599.

5. Bowles Center Alcohol Studies, University of North Carolina, Chapel Hill, NC 27599.

6. Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599.

7. Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599.

Publisher

Mary Ann Liebert Inc

Subject

Genetics,Molecular Biology,Molecular Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/hum.2010.245

Reference30 articles.

1. A segment of the Mecp2 promoter is sufficient to drive expression in neurons

2. Immune responses to gene therapy vectors: influence on vector function and effector mechanisms

3. Mild overexpression of MeCP2 causes a progressive neurological disorder in mice

4. Intravenous Administration of Self-complementary AAV9 Enables Transgene Delivery to Adult Motor Neurons

5. Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

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