Short Inhalation Exposures of the Isolated and Perfused Rat Lung to Respirable Dry Particle Aerosols; the Detailed Pharmacokinetics of Budesonide, Formoterol, and Terbutaline-Reference-Cited by-同舟云学术

Short Inhalation Exposures of the Isolated and Perfused Rat Lung to Respirable Dry Particle Aerosols; the Detailed Pharmacokinetics of Budesonide, Formoterol, and Terbutaline

Published:2008-06 Issue:2 Volume:21 Page:169-180
ISSN:1941-2711
Container-title:Journal of Aerosol Medicine and Pulmonary Drug Delivery
language:en
Short-container-title:Journal of Aerosol Medicine and Pulmonary Drug Delivery

Author:

Ewing Per¹,Eirefelt Stefan J.²,Andersson Paul²,Blomgren Anders²,Ryrfeldt Åke¹,Gerde Per¹

Affiliation:

1. Institute of Environmental Medicine, Karolinska Institutet, S-171 77 Stockholm, Sweden.

2. DMPK Discovery, AstraZeneca, S-221 87, Lund, Sweden. 3 DustGun Technologies AB, Stockholm, Sweden.

Publisher

Mary Ann Liebert Inc

Subject

Pharmacology (medical),Pharmaceutical Science,Pulmonary and Respiratory Medicine

Link

http://www.liebertpub.com/doi/pdf/10.1089/jamp.2007.0654

Reference32 articles.

1. Drug Delivery Takes a Deep Breath

2. Inhaling medicines: delivering drugs to the body through the lungs

3. Inhaled insulin1Abbreviations: DM, diabetes mellitus; AIDs, acquired immune deficiency syndrome; SC, subcutaneous; DCCT, Diabetes Control and Complications Trial; IDDM, insulin-dependent diabetes mellitus; NIDDM, non-insulin-dependent diabetes mellitus; i.v., intravenous; DDPC, di-decanoyl-alpha-phosphatidylcholine; AUC, area under the curve; INH, inhaled; Cmax, maximum serum concentration; Cmin, minimum serum concentration; Tmax, time of maximum serum concentration; NS, not significant; HbA1c, hemoglobin A1c; OA, oral agent; SD, standard deviation; MDI, metered dose inhaler; DPI, dry powder inhaler; MMAD, mass median aerodynamic diameter; CMC, critical micelle concentration; SR, sustained release; PLGA, poly lactic acid-co-glycolic acid; GI, gastrointestinal, GSD, geometric standard deviation; TLC, total lung capacity; VC, vital capacity; SMK, smokers; MW, molecular weight; MP, melting point.1

4. Advances in Asthma and COPD Treatment: Combination Therapy with Inhaled Corticosteroids and Long-Acting β2-Agonists.

5. Pharmacokinetics and systemic activity of fluticasone via Diskus® and pMDI, and of budesonide via Turbuhaler®

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