Affiliation:
1. Institute of Biomedical Chemistry, Russian Academy of Medical sciences
Abstract
This review considers the stages of the development of synthetic peptide vaccines against infectious agents, novel approaches and technologies employed in this process, including bioinformatics, genomics, proteomics, large-scale peptide synthesis, high-throughput screening methods, the use of transgenic animals for modelling human infections. An important role for the development and selection of efficient adjuvants for peptide immunogens is noted. Examples of synthetic peptide vaccine developments against three infectious diseases (malaria, hepatitis C, and foot-and-mouth disease) are given.
Publisher
Institute of Biochemistry
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Cited by
5 articles.
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