Affiliation:
1. The University of Queensland, School of Chemistry and Molecular Biosciences, Cooper Road, St. Lucia QLD 4072, Australia
Abstract
Despite advances in the development of new vaccines, there are still some diseases with no vaccine solutions. Therefore, further efforts are required to more comprehensively discern the different antigenic components of these microorganisms on a molecular level. This review summarizes advancement in the development of new carbohydrate-based vaccines. Following traditional vaccine counterparts, the carbohydrate-based vaccines introduced a new approach in fighting infectious diseases. Carbohydrates have played various roles in the development of carbohydrate-based vaccines, which are described in this review, including carbohydrates acting as antigens, carriers or targeting moieties. Carbohydrate-based vaccines against infectious diseases, such as group A streptococcus, meningococcal meningitis and human immunodeficiency virus, are also discussed. A number of carbohydrate- based vaccines, such as Pneumovax 23, Menveo and Pentacel, have been successfully marketed in the past few years and there is a promising standpoint for many more to come in the near future.
Funder
University of Queensland
National Health and Medical Research Council.
Publisher
Bentham Science Publishers Ltd.
Reference71 articles.
1. Plotkin S.A.; Orenstein W.A.; Offit P.A.; Vaccines 2013
2. Reche P.A.; Fernandez-Caldas E.; Flower D.R.; Fridkis-Hareli M.; Hoshino Y.; Peptide-based immunotherapeutics and vaccines. J Immunol Res 2014
3. Francis D.P.; Successes and failures: Worldwide vaccine development and application. Biologicals 2010,38(5),523-528
4. Wong L.K.S.; Muthupalaniappen L.; Tie S.T.; Knowledge, belief and barriers to adult influenza and pneumococcal vaccination among primary care doctors in sarawak. Med Health 2017,12,275-285
5. Vogel F.R.; Modulation of the immune response to vaccine antigens, 92, F In: Brown and LR Haaheim, eds (Basel: Karger: Development in Biological Standardization), 1998,92,241-248
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献