Crown disease with extrainterinal manifestations in the form of granulematous alveolitis

Author:

Barlamov P. N.1ORCID,Tretyakova Yu. I.1ORCID,Zhelobov V. G.1ORCID,Khlynova O. V.1ORCID

Affiliation:

1. Perm State Medical University named after academician E. Wagner

Abstract

Objective: To present a clinical description of the observation of a patient with Crohn’s disease (CD) with extraintestinal manifestations in the form of granulomatous alveolitis.Materials and Methods: A brief review of the literature on the current understanding of the prevalence and clinical manifestations of lung lesions in inflammatory bowel diseases (IBD) and CD, as well as a description of a patient with this pathology with the results of autopsy is presented.Results: The rare presence of granulomatous lung lesions in a patient with CD was proved.Conclusion: Difficulties in the differential diagnosis and treatment of CD lung lesions are shown. In particular, suspicion of tuberculous lesion, lung abscess creates potential risks of generalization of the process when using such therapeutic effects as glucocorticosteroids, cytostatics, immunosuppressants, biological genetically engineered drugs and active surgical intervention. The authors hope that the described observation will alert doctors in terms of possible systemic pulmonary lesions in CD.

Publisher

LLC Global Media Technology

Subject

Gastroenterology,Hepatology

Reference8 articles.

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2. Zhilin S.A., Radchenko V. G., Dobritsa V. P. Extraintestinal manifestations of inflammatory bowel disease. Vestnik Severo-Zapadnogo gosudarstvennogo meditsinskogo universiteta im. I. I. Mechnikova. 2013; 5(2): 111–117. (in Russian)

3. Zhao Y., Wang J., Liu Z., Lin H., Shi Y., Sun X. Pulmonary dysfunction in 114 patients with inflammatory bowel disease. Medicine (Baltimore). 2017; 96(18): 6808. doi: 10.1097/MD.0000000000006808.

4. Carratú P., Dragonieri S., Nocerino M. C., Trabucco S. M., Lacedonia D., Parisi G., Resta O. A. Сase of cryptogenic organizing pneumonia occurring in Crohn’s disease. Can Respir J. 2005 Nov-Dec;12(8):437–9. doi: 10.1155/2005/784071.

5. Warwick G., Leecy T., Silverstone E., Rainer S., Feller R., Yates D. H. Pulmonary necrobiotic nodules: a rare extraintestinal manifestation of Crohn’s disease. Eur Respir Rev. 2009; 18(111): 47–50. doi: 10.1183/09059180.00011114.

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